CIRM Scholars

2023-24 Cohort

Matt Jones

| Clinical Fellow | Hematology/Oncology | Smith Lab |

Research Topic: Modeling treatment resistant monocytic AML using induced pluripotent stem cells

I am a clinical fellow in hematology/oncology and a post-doc in Catherine Smith's lab, where we study resistance to treatment in acute myeloid leukemia (AML). I am developing induced pluripotent stem cell models of AML to elucidate the mechanisms by which differentiation state influences response to targeted therapy and to empower discovery of more effective therapies for treatment refractory disease. More broadly, I am interested in the interplay between genetics and cell state in determining cancer phenotypes. 
 
I received my DPhil jointly from University of Oxford and NIH, where I was mentored by Sir Walter Bodmer and Ashish Lal. My thesis focused on the roles of non-coding RNAs in regulating cell fate in colorectal cancer. Then I received my MD from The University of Chicago Pritzker School of Medicine where I studied genetic syndromes predisposing to leukemia with Lucy Godley. I completed my residency in internal medicine at UCSF in the Molecular Medicine program, and I am continuing my clinical training in the UCSF Heme/Onc fellowship program. My hobbies include collecting books and vinyl records, cooking overly elaborate meals, skiing, and SCUBA diving. 

Chujing Zhang

| Postdoctoral Fellow | UCSF Weill Institute for Neurosciences | Lim Lab |

Research Topic: Dynamic nuclear compartment-associated genome organization modulates the bivalent chromatin state during human cortical neurogenesis

Ph.D. from the National University of Singapore. Passionate about the development and application of novel methods and analytical tools for the study of biological questions important to human development and diseases. I enjoy reading, cooking, and spending quality time with family and friends.

Roberto Castro Gutierrez

| Postdoctoral Fellow | Department of Surgery | Tang Lab |

Research Topic: Protecting stem cell derived beta cells from immune rejection using targeted Treg technology

My name is Roberto Castro Gutierrez, and I earned my PhD degree in Molecular Biology at the University of Colorado Anschutz Medical Campus. My PhD dissertation focused on regenerative medicine, more specifically the generation of insulin producing beta cells from stem cells.

Now at the Tang lab, I am working on the generation of tissue specific regulatory T cell (Treg) therapies. Using genetic engineering of T cell receptors (TCRs) and Chimeric Antigen Receptors (CARs), the immunosuppressive role of Tregs can be directed towards specific targets, including the insulin producing beta cell. I will employ these methods to develop functional Tregs that can be used to protect insulin producing beta cells from immune destruction in Type 1 Diabetes. Outside the lab I enjoy running at the Golden Gate park and playing a variety of sports like basketball, soccer, and volleyball. 

Sarah Fong

| Postdoctoral Fellow | Department of Bioengineering and Therapeutic Sciences | Ahituv Lab |

Research Topic: Engineering electromagnetic-controlled gene regulation to induce osteoblast differentiation

I am a post-doctoral researcher in Dr. Nadav Ahituv’s lab. My research goal is to engineer regulatory elements that precisely control gene expression for gene therapy applications. I use computational and deep neural network approaches to learn and optimize cell-type-specific and environmental factors that drive gene regulation in neurons, fibroblast, liver cells, and osteoblast progenitors. I received my Ph.D. in Human Genetics from Vanderbilt University, where I researched evolutionary divergence and human genetics of mammalian gene regulatory elements with Dr. Tony Capra. Outside of lab, I enjoy running, seeing friends, and playing Debussy on the piano.

Hannah Greenfeld

| Postdoctoral Fellow | Department of Obstetrics, Gynecology & Reproductive Sciences | Wagner Lab |

Research Topic: Decoding BMP signaling during patterning of the dorsal neural tube

My name is Hannah Greenfeld and I am a postdoc in Dan Wagner's lab investigating how morphogen signaling patterns the dorsal neural tube. I received my B.S. from the University of Wisconsin – Madison and completed my PhD at the University of Pennsylvania. As a PhD student in Mary Mullins’ lab, I studied how BMP signaling was interpreted to pattern the dorsal-ventral body axis during gastrulation. When outside the lab, I have been enjoying weightlifting, knitting, and exploring the national parks in California!

 

Wei Jiang

| Postdoctoral Fellow | Cardiovascular Research Institute | Ma Lab |

Research Topic: Translating extremotolerant physiology into gene therapy for alleviating ischemic injuries

My name is Wei Jiang and I am a post-doctoral in Dr. Ma’s Laboratory, where I am studying how genes make cells stress resilient and organisms adapt to environment stresses, including hypoxia (low oxygen) or high temperature (heat). Before joining the Ma Lab, I completed my Ph.D.’s degree and first post-doctoral in neuroscience with a specialization in ischemic stroke from Hunan University in China. Outside of the lab, I love taking afternoon walks. 

Tsukasa Kadota

| Postdoctoral Fellow | Dept. of Medicine (Pulmonary) | Peng Lab |

Research Topic: Stromal factor promotes transdifferentiation of metaplastic basal stem cells into alveolar type 2 cells in the fibrotic lung

My name is Tsukasa Kadota, and I am a postdoctoral researcher in Dr. Tien Peng's lab. My work focuses on developing therapies that can reverse differentiated pathological cells back into endogenous stem cells in the diseased lung. I earned my M.D. and Ph.D. degrees from The Jikei University School of Medicine in Tokyo, Japan, where I studied the role of extracellular vesicles in the pathogenesis of pulmonary fibrosis. Outside of the lab, I enjoy hiking and exploring California's national parks with my family.

 

Lina Afonso

| Graduate Student | Department of Cellular Molecular Pharmacology | Fattahi Lab |

Research Topic: Defining the role of R. gnavus's and B. thetaiotaomicron's and their metabolite, tryptamine in the Enteric Nervous System

My name is Lina Afonso and  I was born and raised in San Francisco, CA. After graduating from the University of California, Berkeley with a BA in Molecular and Cell Biology, I went on to work at UCSF for a few years, eventually deciding to pursue my PhD in Developmental and Stem Cell Biology. In 2022, I joined the Fattahi lab, where I am currently researching the microbiome metabolite interactions with the enteric nervous system (ENS) and the impact of neuromodulators on colon motility in the ENS. In my free time, I enjoy swimming, biking, and hiking.

 

Elena Turkalj

| Graduate Student | Department of Biochemistry and Biophysics | Vissers Lab |

Research Topic: Elucidating the role of rRNA methylation in neural development using forebrain organoids

Hi I’m Elena and I’m a graduate student in the developmental and stem cell biology program. I have a B.S. in Neuroscience and Physiology and a M.S. in Biology from UC San Diego. During my Masters, I studied how bacteria (Pseudomonas syringae) inject virulent proteins that change the circadian rhythms in plants. My Masters research sparked my interest in molecular dynamics at the cellular level and at the organism level. Now, I am in the Vissers lab studying the role of ribosomal RNA methylation on proper neurodevelopment using forebrain organoids. Basically, how do those dynamic RNA methylation events effect neural differentiation over time. My major goal in life is to develop real-time tools to continuously monitor human hormones and other dynamic proteins to provide insight into how the human body functions. In my free time, you can find me exploring new coffee shops, baking gluten-free goods, or spending time outdoors.

Li Wang

| Graduate Student | Department of Urology | Blelloch Lab |

Research Topic: Role of Tumor Derived Exosomes in Immune Cell Differentiation and Metastasis

My name is Li. I am a BMS graduate student in Robert Blelloch’s lab. I graduated with a B.S. in Human Biology and an M.S. in Biology from UC San Diego. In my undergraduate and master's research, I studied the genetic and molecular mechanisms underlying cardiomyopathies. My current research focuses on understanding the role of the immune system in cancer metastasis. I am particularly interested in the mechanisms by which tumor cells alter immune cell states, and how the differential tumor cell-immune cell interactions impact metastatic outcomes. Outside of research, I enjoy photography, trying out coffee shops, hiking, and reading.